Research on Quality Control Model of Ancient Famous Classical Formulas Based on Supramolecular Theory / 中国实验方剂学杂志

The ancient famous classical formulas were developed based on the characteristics of excellent curative effect, small toxic and side effects, and wide clinical application. Its development will promote the development of traditional Chinese medicine (TCM) with huge social and economic benefits. TCM and TCM compounds are multi-component systems, which are multi-component, multi-target and multi-pathway effect on human body, their curative effect is the result of synergistic effect of multi-component. Because of its characteristics, its mechanism of action is still unclear and quality is difficult to control. Therefore, on the basis of biological properties of the multi-components of TCM, it is the key issue to study the preparation process of the medicinal materials-decoction pieces-preparations and the transferability, stability and homogeneity of the quality attributes. Moreover, the supramolecular theory can explain the basic theory of TCM from the macroscopic and microscopic aspects, the study of ancient famous classical formulas can use the supramolecular theory. Both TCM and human body are giant complex supramolecules, and their components are clustered objects reflecting the characteristics of the original imprinting template with genetic polymorphism. The quality attributes, processing, formulation preparation and quality attribute evaluation of TCM are all affected by supramolecular chemistry, which is finally reflected in the preparation of imprinting template and the transfer law of quality properties. Therefore, the application of supramolecular imprinting template theory to study the biogenetic polymorphism of TCM, processing, formulation preparation and quality attribute evaluation of medicinal materials can improve the availability rate of successful research and development of ancient famous classical formulas.

Network meta-analysis: application and practice using R software / 한국역학회지

The objective of this study is to describe the general approaches to network meta-analysis that are available for quantitative data synthesis using R software. We conducted a network meta-analysis using two approaches: Bayesian and frequentist methods. The corresponding R packages were “gemtc” for the Bayesian approach and “netmeta” for the frequentist approach. In estimating a network meta-analysis model using a Bayesian framework, the “rjags” package is a common tool. “rjags” implements Markov chain Monte Carlo simulation with a graphical output. The estimated overall effect sizes, test for heterogeneity, moderator effects, and publication bias were reported using R software. The authors focus on two flexible models, Bayesian and frequentist, to determine overall effect sizes in network meta-analysis. This study focused on the practical methods of network meta-analysis rather than theoretical concepts, making the material easy to understand for Korean researchers who did not major in statistics. The authors hope that this study will help many Korean researchers to perform network meta-analyses and conduct related research more easily with R software.

Network meta-analysis: application and practice using R software / 한국역학회지

The objective of this study is to describe the general approaches to network meta-analysis that are available for quantitative data synthesis using R software. We conducted a network meta-analysis using two approaches: Bayesian and frequentist methods. The corresponding R packages were “gemtc” for the Bayesian approach and “netmeta” for the frequentist approach. In estimating a network meta-analysis model using a Bayesian framework, the “rjags” package is a common tool. “rjags” implements Markov chain Monte Carlo simulation with a graphical output. The estimated overall effect sizes, test for heterogeneity, moderator effects, and publication bias were reported using R software. The authors focus on two flexible models, Bayesian and frequentist, to determine overall effect sizes in network meta-analysis. This study focused on the practical methods of network meta-analysis rather than theoretical concepts, making the material easy to understand for Korean researchers who did not major in statistics. The authors hope that this study will help many Korean researchers to perform network meta-analyses and conduct related research more easily with R software.

A linguistic analysis of transitivity in delusional speech: a case study / Uma análise linguística da transitividade em discurso delirante: um estudo de caso

This article presents results of a research that investigated some syntactic and semantic aspects of the expression of delusional events in the discourse of a person with schizophrenia. Based on Cognitive Linguistics (CL), we analyzed 1104 clause units taken from her speech. The case analyzed shows a specific linguistic syntactic pattern related to the expression of delusional events. Results indicate a highly significant relation between the transitive construction and the clause units involving delusional entities (χ²(1, N=98) = 45.097, p<.0001) and also a significantdifference in the mean of transitivity rate in these clause units (t(80)=2.71, p=.008). These results were interpreted as evidence of a schematic conceptual core, i.e., a prototypical schematic cognitive structure associated to delusion. These findings suggest, albeit in a preliminary way, the possibility of describing delusion also on a linguistic basis

Este artigo apresenta os resultados de uma pesquisa que investigou alguns aspectos sintáticos e semânticos ligados às estruturas que compõem o discurso delirante de uma paciente com esquizofrenia. Com base no quadro teórico da Linguística Cognitiva, foram analisadas 1104 unidades oracionais que compõem o discurso dessa paciente. O caso analisado mostra um padrão sintático específico relacionado a essas estruturas. Os resultados indicam uma relação altamente significativa entre a construção transitiva e as unidades oracionais que envolvem entidades delirantes(χ²(1, N=98) = 45.097, p<.0001), assim como uma diferença significativa na transitividade média dessas unidades oracionais (t(80)=2.71, p=.008). Esses resultados foram interpretados como uma evidência de um núcleo conceptual esquemático, i.e, uma estrutura cognitiva esquemática e prototípica associada ao delírio. Esses achados sugerem, ainda que de maneira preliminar, a possibilidade dese descrever o discurso delirante em uma base linguística

Histórico das relações entre filosofia e medicina no curso de Michel Henry em Portugal e as relações com a psicologia clínica / History of the relationship between philosophy and medicine in the course of Michel Henry in Portugal and relations with clinical psychology / Histoire des relations entre la philosophie et la médecine au cours de Michel Henry au Portugal et les relations avec la psychologie clinique / Histórico de las relaciones entre filosofía y medicina en el curso de Michel Henry en Portugal y las relaciones con la psicología clínica

Será apresentado um breve histórico das relações entre a fenomenologia da vida desenvolvida pelo filósofo francês Michel Henry (1922-2002) e a medicina, como se deram em Portugal, para delas explorarmos as possibilidades de interdisciplinaridade com a psicologia clínica, no Brasil. Focaliza-se a fenomenalidade do imprevisível na vida cotidiana, que fragiliza e desestrutura o ser humano, e com a qual o terapeuta trabalha constantemente. Assim, atendemos a constantes transitividades afetivas de nossas vivências clínicas, que ocorrem sempre em comunidade. Então, para que essa relação seja legitimada cientificamente, é necessário que o terapeuta constitua uma comunidade com as várias ciências unidas no processo, de modo que repensar a interdisciplinaridade torna-se indispensável para o psicólogo.

A brief history of the relationship between the phenomenology of life, developed by the French philosopher Michel Henry (1922-2002), and medicine, in Portugal, will be presented to explore the possibilities of interdisciplinarity with clinical psychology in Brazil. The focus is the phenomenality of the unpredictable in everyday life that weakens and disrupts the human being and with which the therapist constantly works. Thus, we attend to the constant affective transitivities of our clinical experiences, which always occur in community. Then, for this relationship to be scientifically validated, it is necessary that the therapist constitutes a community with the various sciences united in this process, so rethinking interdisciplinarity becomes essential for the psychologist.

Il sera présenté un bref historique des relations entre la phénoménologie de la vie, développée par le philosophe Michel Henry (1922-2002) et la médecine, comment il est arrivé au Portugal, pour examiner les possibilités d'interdisciplinarité avec la psychologie clinique au Brésil. On se concentrera sur la phénoménologie de l´imprévisible dans la vie quotidienne qui fragilise et déstructure l'être humain, avec lequel le thérapeute travaille sans cesse. Nous avons ainsi faire attention à des constantes transitivités affectives de nos vécus cliniques qui surviennent toujours en communauté. Pour que cette relation soit scientifiquement efficace ou valide, il faut que le thérapeute constitue une communauté avec les différentes sciences unies dans ce processus. Ainsi, repenser l´interdisciplinarité devient indispensable au psychologue.

Será presentado un breve histórico de las relaciones entre la fenomenología de la vida desarrollada por el filósofo francés Michel Henry (1922-2002) y la medicina, como llegó a Portugal y las posibilidades de la interdisciplinariedad con la psicología clínica en Brasil. Se focalizó la fenomenalidad del imprevisible en la vida cotidiana, que debilita y desestructura el ser humano, la cual el terapeuta trabaja constantemente. Así, atendemos a constantes transitividades afectivas de nuestras vivencias clínicas, que operan siempre en comunidad. Para que esta relación sea científicamente eficaz o valida, es necesario que el terapeuta constituya comunidad con las varias ciencias unidas en este proceso, de modo que repensar la interdisciplinariedad tornase indispensable para el psicólogo.

Modelo de transitividad aplicado a la gestión de la salud mental comunitaria / Transitivity model applied to the management of mental health community

Introducción: El modelo de transitividad constituye un paradigma de intervención social fundamentado en la condición auto-organizadora de la comunidad como garante de sus propios procesos. Objetivo: Validar los postulados del modelo de transitividad en la dinamización de escenarios clínico comunitarios para la gestión de la salud mental en el Municipio de San Lorenzo - Nariño en el año 2013. Materiales y métodos: El estudio se desarrolló desde el paradigma cualitativo a través de la investigación, acción participativa. Resultados: El modelo de transitividad favorece el tránsito homeostasis - acomodación potenciando la dimensión participativa del sujeto en la transformación de estructuras sociales desde la generación de políticas públicas que garanticen la planificación y ejecución de escenarios en torno a la dinamización participativa de la salud mental comunitaria del Municipio. Conclusión: Los resultados del estudio resaltan la importancia del modelo de transitividad en la gestión de la salud mental comunitaria, al proveer herramientas de intervención que permiten involucrar a las comunidades como agentes transformadores de estados previos de acomodación a estados finales de homeostasis que garantizan la salud mental y el bienestar colectivo de sus comunidades.

Introduction: The transitivity model is a paradigm of social intervention based on self-organizing community status as guarantor of its own processes. Objective: To validate the postulates of transitivity model in the revitalization of community clinical scenarios for the management of mental health in the municipality of San Lorenzo - Nariño in 2013. Materials and methods: The study was developed from the qualitative paradigm through participatory action research. Results: The transitivity model promotes transit homeostasis - accommodation, potentiating the participatory dimension of the subject in the transformation of social structures from the creation of public policies that ensure the planning and implementation of scenarios around participatory revitalization of community mental health in the Municipality. Conclusion: The results of the study highlight the importance of transitivity model in managing community mental health by providing intervention tools that enable engaging communities as agents of transformation of previous states of accommodation to final states of homeostasis that guarantee mental health and collective welfare of their communities.

Transitividad: produciendo Rizoma en medio de Winnicott, Guattari y Deleuze / Transitivity: producing Rhizome amid Winnicott, Guattari and Deleuze / Transitividade: produzindo Rizoma no meio de Winnicott, Guattari e Deleuze

El objetivo de este escrito es articular epistemológicamente las enseñanzas clínicas de Donald Winnicott y el pensamiento filosófico de Félix Guattari y Gilles Deleuze. Aborda específicamente los puntos de intercepción entre el concepto de lo transicional y el de agenciamiento maquínico, con base en la hipótesis de trabajo sobre una referencia común al problema de la producción transitiva de signos, que se despliega en medio de un mismo plano de inmanencia, en el que operan compositivamente una multiplicidad de elementos para la formación consistente de sistemas acentrados y mutables. Para este ejercicio se recurre especialmente al artículo del psicoanalista inglés: "Objetos transicionales y fenómenos transicionales" (1951/2008b), publicado en la edición póstuma de La Realidad y el Jugar (1971/2008a), así como al escrito de los filósofos franceses: "Rizoma", editado en Mil Mesetas (1980/2006).

O objetivo deste trabalho é articular epistemologicamente os ensinos clínicos de Donald Winnicott e pensamento filosófico de Gilles Deleuze e Felix Guattari . Aborda especificamente os pontos de intersecção entre o conceito do transicional e o agenciamento maquínico, com base na hipótese de trabalho de uma referência comum para o problema da produção transitiva de sinais, que se desdobra em meio a um mesmo plano de imanência, no qual operam compositivamente uma multiplicidade de elementos para a formação consistente de sistemas acentrados e mutáveis ​​. Para este exercício, se recorre especialmente ao artigo do psicanalista inglês: "objetos transicionais e fenômenos transicionais" ( 1951/2008b ) , publicado na edição póstuma de Realidade e Jogo ( 1971/2008a ), bem como ao escrito dos filósofos franceses " Rizoma " , publicado em Mil Platôs (1980 /2006).

The purpose of this paper is to epistemologically articulate the clinics teachings of Donald Winnicott and philosophical thought of Felix Guattari and Gilles Deleuze. It specifically addresses the points of interception between the concept of the transitional and the machinic assemblage, based on the working hypothesis of a common reference to the transitive production of signs, that unfolds in the midst of one plane of immanence in which operate compositionally a multiplicity of elements for consistent training ofuncentered and mutable systems. For this exercise are used especially the article of english psychoanalyst ®Transitional objects and transitional phenomenas¼ (1951/2008b), published in the posthumous edition of Playing and Reality (1971/2008a), and the text of french philosophers: ®Rhizome¼, published in A Thousand Plateaus (1980/2006).